Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk

A growing literature suggests that circulating cholesterol levels have been associated with Parkinson's disease (PD). In this study, we investigated a possible causal basis for the cholesterol-PD link. Fasting plasma cholesterol levels were obtained from 91 PD and 70 age- and gender-matched con...

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Bibliographic Details
Published in:Frontiers in neurology 2017-09, Vol.8, p.501
Main Authors: Zhang, Lijun, Wang, Xue, Wang, Ming, Sterling, Nick W, Du, Guangwei, Lewis, Mechelle M, Yao, Tao, Mailman, Richard B, Li, Runze, Huang, Xuemei
Format: Article
Language:English
Subjects:
cholesterol
genetics
Neuroscience
Parkinson’s disease
propensity score
statins
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Summary:A growing literature suggests that circulating cholesterol levels have been associated with Parkinson's disease (PD). In this study, we investigated a possible causal basis for the cholesterol-PD link. Fasting plasma cholesterol levels were obtained from 91 PD and 70 age- and gender-matched controls from an NINDS PD Biomarkers Program cohort at the Pennsylvania State University College of Medicine. Based on the literature, genetic polymorphisms in selected cholesterol management genes (APOE, LDLR, LRP1, and LRPAP1) were chosen as confounding variables because they may influence both cholesterol levels and PD risk. First, the marginal structure model was applied, where the associations of total- and LDL-cholesterol levels with genetic polymorphisms, statin usage, and smoking history were estimated using linear regression. Then, potential causal influences of total- and LDL-cholesterol on PD occurrence were investigated using a generalized propensity score approach in the second step. Both statins (  
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2017.00501