Early neutrophil gelatinase‐associated lipocalin (NGAL) measurement could rule out future acute kidney injury in patients with acute coronary syndrome—Prospective observational study

Background and Aims The diagnosis of acute kidney injury (AKI) is of importance among patients with ST segment elevation (STEMI) undergoing primary coronary intervention (PCI). It is often delayed given the need in serial measurements of creatinine or other serum markers. Neutrophil gelatinase‐assoc...

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Bibliographic Details
Published in:Health science reports 2024-07, Vol.7 (7), p.e2229-n/a
Main Authors: Magnusson, Nils Erik, Frydman, Shir, Freund, Ophir, Zornizki, Lior, Banai, Shmuel, Shacham, Yacov
Format: Article
Language:English
Subjects:
ACS
Acute coronary syndromes
AKI
Biomarkers
cardiorenal
Creatinine
Ejection fraction
Hypertension
Inflammation
Kidney diseases
Neutrophils
NGAL
prediction
Proteins
Variables
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Summary:Background and Aims The diagnosis of acute kidney injury (AKI) is of importance among patients with ST segment elevation (STEMI) undergoing primary coronary intervention (PCI). It is often delayed given the need in serial measurements of creatinine or other serum markers. Neutrophil gelatinase‐associated lipocalin (NGAL) is a proven marker for AKI, although its role as an early predictor in this setting was scarcely addressed before and was the aim of our study. Methods Prospective observational study including 133 patients with STEMI treated with PCI. Plasma NGAL was drawn immediately before PCI (NGAL‐0) and 24 h after (NGAL‐24). Similar analysis of C‐reactive protein (CRP) was performed for additional comparison. Results Mean age was 62 ± 13 years, 78% were men, and 20 (15%) developed AKI after admission. Patients with AKI after admission demonstrated higher levels of NGAL‐0 (164 vs. 95 ng/mL; p 
ISSN:2398-8835
2398-8835
DOI:10.1002/hsr2.2229