In Silico functional and phylogenetic analyses of fungal immunomodulatory proteins of some edible mushrooms

Mushrooms are a well known source of many bioactive and nutritional compounds with immense applicability in both the pharmaceutical and food industries. They are widely used to cure various kinds of ailments in traditional medicines. They have a low amount of fats and cholesterol and possess a high...

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Bibliographic Details
Published in:AMB Express 2022-12, Vol.12 (1), p.159-159, Article 159
Main Authors: Ramlal, Ayyagari, Samanta, Aveek
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor agents
Bioactive peptides
Biomedical and Life Sciences
Biotechnology
Cholesterol
Conserved sequence
Diseases
Food industry
Fungal immunomodulatory proteins (FIPs)
Fungi
Immunomodulation
Immunomodulators
Immunostimulation
Life Sciences
Microbial Genetics and Genomics
Microbiology
Motifs
Mushrooms
Original
Original Article
Phylogenetics
Phylogeny
Proteins
Traditional medicines
Tumors
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Summary:Mushrooms are a well known source of many bioactive and nutritional compounds with immense applicability in both the pharmaceutical and food industries. They are widely used to cure various kinds of ailments in traditional medicines. They have a low amount of fats and cholesterol and possess a high number of proteins. Immunomodulators have the ability which can improve immunity and act as defensive agents against pathogens. One such class of immunomodulators is fungal immunomodulatory proteins (FIPs). FIPs have potential roles in the treatment of cancer, and immunostimulatory effects and show anti-tumor activities. In the current study, 19 FIPs from edible mushrooms have been used for comparison and analysis of the conserved motifs. Phylogenetic analysis was also carried out using the FIPs. The conserved motif analysis revealed that some of the motifs strongly supported their identity as FIPs while some are novel. The fungal immunomodulatory proteins are important and have many properties which can be used for treating ailments and diseases and this preliminary study can be used for the identification and functional characterization of the proposed novel motifs and in unraveling the potential roles of FIPs for developing newer drugs.
ISSN:2191-0855
2191-0855
DOI:10.1186/s13568-022-01503-w