Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes

Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation...

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Bibliographic Details
Published in:Metabolites 2024-06, Vol.14 (7), p.361
Main Authors: Saucedo, Renata, Ferreira-Hermosillo, Aldo, Robledo-Clemente, Magalhi, Díaz-Velázquez, Mary Flor, Valencia-Ortega, Jorge
Format: Article
Language:English
Subjects:
Adipose tissue
Biomarkers
Birth weight
Body fat
Cardiovascular diseases
Diabetes mellitus (non-insulin dependent)
DNA methylation
Epigenetics
Fetuses
gestational diabetes
Growth factors
Infants
Insulin resistance
macrosomia
Metabolic syndrome
Molecular modelling
Offspring
Phenotypes
Pregnancy complications
Womens health
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Summary:Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation of several hormones, cytokines, and growth factors related to fetal fat mass growth. One of the molecular mechanisms of GDM influencing these factors is epigenetic alterations, such as DNA methylation (DNAm). This review will examine the role of DNAm as a potential biomarker for monitoring fetal growth during pregnancy in women with GDM. This information is relevant since it may provide useful new biomarkers for the diagnosis, prognosis, and treatment of fetal growth and its later-life health consequences.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo14070361