Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus

In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. ZnO@GA nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant a...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2017-11, Vol.7 (11), p.365
Main Authors: Lee, Joomin, Choi, Kyong-Hoon, Min, Jeeeun, Kim, Ho-Joong, Jee, Jun-Pil, Park, Bong Joo
Format: Article
Language:English
Subjects:
Antibacterial activity
antibiotic resistance
Antioxidants
antioxidative activity
Bacteria
Bactericidal activity
Chemical bonds
Drug resistance
E coli
Gallic acid
Gram-negative bacteria
Gram-positive bacteria
Methicillin
methicillin-resistant Staphylococcus aureus
Nanoparticles
Selectivity
Staphylococcus aureus
Staphylococcus infections
Strains (organisms)
Sulfonic acid
Zinc oxide
ZnO@GA
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Summary:In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. ZnO@GA nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,2'-azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria ( ), including several strains of methicillin-resistant (MRSA), and Gram-negative bacteria ( ). The functionalized ZnO@GA nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to use it as an antibacterial agent for removing MRSA.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano7110365