Movement-related coupling of human subthalamic nucleus spikes to cortical gamma

Cortico-basal ganglia interactions continuously shape the way we move. Ideas about how this circuit works are based largely on models those consider only firing rate as the mechanism of information transfer. A distinct feature of neural activity accompanying movement, however, is increased motor cor...

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Bibliographic Details
Published in:eLife 2020-03, Vol.9
Main Authors: Fischer, Petra, Lipski, Witold J, Neumann, Wolf-Julian, Turner, Robert S, Fries, Pascal, Brown, Peter, Richardson, R Mark
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Basal ganglia
Communication
Cortical Synchronization
Deep Brain Stimulation
ECoG
Electrical stimuli
Electrocorticography
Electrophysiological Phenomena
Firing rate
gamma oscillations
Humans
Motor Activity - physiology
motor control
Motor Cortex - physiology
Neural Pathways - physiology
Neurons - physiology
Neuroscience
Parkinson Disease
Parkinson's disease
Phase shift
Solitary tract nucleus
spike coupling
Subthalamic nucleus
Subthalamic Nucleus - physiology
Topography
Unit activity
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Summary:Cortico-basal ganglia interactions continuously shape the way we move. Ideas about how this circuit works are based largely on models those consider only firing rate as the mechanism of information transfer. A distinct feature of neural activity accompanying movement, however, is increased motor cortical and basal ganglia gamma synchrony. To investigate the relationship between neuronal firing in the basal ganglia and cortical gamma activity during movement, we analysed human ECoG and subthalamic nucleus (STN) unit activity during hand gripping. We found that fast reaction times were preceded by enhanced STN spike-to-cortical gamma phase coupling, indicating a role in motor preparation. Importantly, increased gamma phase coupling occurred independent of changes in mean STN firing rates, and the relative timing of STN spikes was offset by half a gamma cycle for ipsilateral vs. contralateral movements, indicating that relative spike timing is as relevant as firing rate for understanding cortico-basal ganglia information transfer.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.51956