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Occurrence of bile alcohols in the bile of a patient with cholestasis

Considerable amounts (6.0 mumol/ml of bile) of bile alcohols were found in the bile of a patient with cholestasis due to gallstones in a common bile duct. Acid hydrolysis of the bile salts followed by chromatographic separation yielded three bile alcohols, which were identified as 26,27-dinor-5 beta...

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Bibliographic Details
Published in:Journal of lipid research 1980-07, Vol.21 (5), p.594-599
Main Authors: Kibe, A, Nakai, S, Kuramoto, T, Hoshita, T
Format: Article
Language:English
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Summary:Considerable amounts (6.0 mumol/ml of bile) of bile alcohols were found in the bile of a patient with cholestasis due to gallstones in a common bile duct. Acid hydrolysis of the bile salts followed by chromatographic separation yielded three bile alcohols, which were identified as 26,27-dinor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25-pentol, 24-methyl-26,-27-dinor-5 beta-cholestane-3 alpha,7 alpha, 24-tetrol, and 3 alpha,7 alpha, 12 alpha-trihydroxy-26,27-dinor-5 beta-cholestan-24-one by comparison with synthetic reference standards.
ISSN:0022-2275
1539-7262
DOI:10.1016/S0022-2275(20)42229-1