Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke

Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and M...

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Published in:BMC genetics 2010-03, Vol.11 (1), p.40-40, Article 40
Main Authors: Manso, Helena, Krug, Tiago, Sobral, João, Albergaria, Isabel, Gaspar, Gisela, Ferro, José M, Oliveira, Sofia A, Vicente, Astrid M
Format: Article
Language:English
Subjects:
Adult
Angiogenesis
Brain - metabolism
Brain research
Female
Gene expression
Gene Frequency
Genetic aspects
Genomics
Genotype
Haplotypes
Hospitalization
Hospitals
Humans
Hypotheses
Male
Matrix Metalloproteinase 2 - genetics
Matrix Metalloproteinase 9 - genetics
Medical imaging
Middle Aged
Patient outcomes
Patients
Physiological aspects
Polymorphism, Single Nucleotide
Proteases
Quality control
Risk factors
Single nucleotide polymorphisms
Software
Stroke (Disease)
Stroke - genetics
Stroke - therapy
Studies
Time Factors
Treatment Outcome
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Summary:Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery. In the present study, the role of MMP-2 and MMP-9 genetic variants in stroke recovery was investigated in 546 stroke patients. Functional outcome was assessed three months after a stroke episode using the modified Rankin Scale (mRS), and patients were classified in two groups: good recovery (mRS 1). Haplotype tagging single nucleotide polymorphisms (SNPs) in the MMP-2 (N = 21) and MMP-9 (N = 4) genes were genotyped and tested for association with stroke outcome, adjusting for significant non-genetic clinical variables. Six SNPs in the MMP-2 gene were significantly associated with stroke outcome (0.0018
ISSN:1471-2350
1471-2156
1471-2350
1471-2156
DOI:10.1186/1471-2350-11-40