Three cases of difficulty in achieving definitive loss of consciousness with remimazolam

Background Remimazolam is a novel, ultra-short-acting benzodiazepine used for general anesthesia. Because remimazolam is an emerging drug, the tolerance to remimazolam in benzodiazepine-taking patients has been unclear. Also, the efficacy of remimazolam in different races is not fully elucidated so...

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Bibliographic Details
Published in:JA clinical reports 2022-01, Vol.8 (1), p.4-4, Article 4
Main Authors: Miyanishi, Mao, Yaguramaki, Toru, Maehara, Yasuhiro, Nagata, Osamu
Format: Article
Language:English
Subjects:
Anesthesiology
Benzodiazepine
Benzodiazepines
Binding sites
Bispectral index
Blood pressure
Case Report
Consciousness
Critical Care Medicine
Drug dosages
Emergency Medicine
Extubation
Fainting
General anesthesia
Hysterectomy
Intensive
Intubation
Medicine
Medicine & Public Health
Pain Medicine
Patients
Remimazolam
Surgery
Tolerance
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Summary:Background Remimazolam is a novel, ultra-short-acting benzodiazepine used for general anesthesia. Because remimazolam is an emerging drug, the tolerance to remimazolam in benzodiazepine-taking patients has been unclear. Also, the efficacy of remimazolam in different races is not fully elucidated so far. Case presentation Here we experienced three cases in which high dose of remimazolam was needed for attempting to achieve appropriate anesthetic depth. Two of the three cases were of preoperatively benzodiazepine-taking patients. The other was a case of a Chinese patient. In all three cases, conversion to general anesthesia with propofol was necessitated. Conclusions When signs of inadequate sedative effect of remimazolam are observed in patients of benzodiazepine users or of different races, conversion to another sedative agent such as propofol should be considered.
ISSN:2363-9024
2363-9024
DOI:10.1186/s40981-021-00485-1