Optimization of megakaryocyte trapping for platelet formation in microchannels

Platelets (PLTs) are responsible for stopping bleeding. They are small cell fragments produced from megakaryocytes (MKs) in the bone marrow. Low platelet count is a significant health problem for a patient. PLTs can usually be stored for up to 5 days prior to transfusion. Instantaneous production of...

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Published in:Chemical Industry & Chemical Engineering Quarterly 2022-01, Vol.28 (1), p.19-28
Main Authors: Baydar-Atak, Gunay, Insel, Mert, Oruc, Muhammed, Sadikoglu, Hasan
Format: Article
Language:English
Subjects:
biotechnology
Blood platelets
Bone marrow
comsol multiphysics
Design
Dynamic structural analysis
Flow velocity
Fluid dynamics
Investigations
mathematical modeling
Microchannels
Microfluidics
Optimization
Physiology
platelet
Platelets
Response surface methodology
Semiconductors
Shear stress
Transfusion
Trapping
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creator Baydar-Atak, Gunay
Insel, Mert
Oruc, Muhammed
Sadikoglu, Hasan
description Platelets (PLTs) are responsible for stopping bleeding. They are small cell fragments produced from megakaryocytes (MKs) in the bone marrow. Low platelet count is a significant health problem for a patient. PLTs can usually be stored for up to 5 days prior to transfusion. Instantaneous production of PLTs from isolated and stored MKs is crucial for the patient?s health. Thanks to microfluidic platforms, PLTs can be produced instantaneously from MKs. Herein, we have computationally studied fluid dynamics in the microchannels with slit structures and different inlet geometries. Analysis of the flow dynamics was performed by the commercial analysis software. The effects of flow rates and the angle between the inlet channels on the MKs trapping were investigated. The optimization of the angle between inlet channels and flow rates of main and pressure flows was done with response surface methodology (RSM) by counting the trapped MKs. The optimum conditions lead to the percentage of trapped MKs being 100 with a relative deviation of
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source Alma/SFX Local Collection
subjects biotechnology
Blood platelets
Bone marrow
comsol multiphysics
Design
Dynamic structural analysis
Flow velocity
Fluid dynamics
Investigations
mathematical modeling
Microchannels
Microfluidics
Optimization
Physiology
platelet
Platelets
Response surface methodology
Semiconductors
Shear stress
Transfusion
Trapping
title Optimization of megakaryocyte trapping for platelet formation in microchannels
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