RhoGTPase in Vascular Disease

Ras-homologous (Rho)A/Rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. Given its role in man...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-06, Vol.8 (6), p.551
Main Authors: Strassheim, Derek, Gerasimovskaya, Evgenia, Irwin, David, Dempsey, Edward C, Stenmark, Kurt, Karoor, Vijaya
Format: Article
Language:English
Subjects:
Apoptosis
Asthma
Atherosclerosis
Cardiovascular disease
Cardiovascular diseases
Cell division
Clinical Trials as Topic
Contraction
endothelial
Fibroblasts
Fibroblasts - cytology
Fibroblasts - metabolism
GTPase-Activating Proteins - metabolism
Guanine Nucleotide Exchange Factors - metabolism
Humans
Hypertension
Hypoxia
Inflammation
Ischemia
Kinases
Localization
Lungs
Medicine
Muscle contraction
Myocytes, Smooth Muscle - metabolism
Oxidative stress
Permeability
Phosphorylation
Proteins
Reactive Oxygen Species - metabolism
Review
Rho-associated kinase
rho-Associated Kinases - metabolism
rhoA GTP-Binding Protein - metabolism
RhoA protein
RhoGTPases
Sepsis
Smooth muscle
therapeutics
Thrombosis
Tumor necrosis factor-TNF
vascular
Vascular diseases
Vascular Diseases - metabolism
Vascular Diseases - pathology
Vascular Diseases - therapy
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Summary:Ras-homologous (Rho)A/Rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. Given its role in many physiological and pathological functions, targeting can result in adverse effects and limit its use for therapy. In this review, we have summarized the role of RhoGTPases with an emphasis on RhoA in vascular disease and its impact on endothelial, smooth muscle, and heart and lung fibroblasts. It is clear from the various studies that understanding the regulation of RhoGTPases and their regulators in physiology and pathological conditions is required for effective targeting of Rho.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8060551