The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold

The 1,2,3-dithiazole is an underappreciated scaffold in medicinal chemistry despite possessing a wide variety of nascent pharmacological activities. The scaffold has a potential wealth of opportunities within these activities and further afield. The 1,2,3-dithiazole scaffold has already been reporte...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-04, Vol.28 (7), p.3193
Main Authors: Kalogirou, Andreas S, Oh, Hans J, Asquith, Christopher R M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
antibacterial
anticancer
antifibrotic
antifungal
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
antimicrobial
antiviral
Antiviral Agents - pharmacology
Biology
Chemistry
Chloride
Fungicides
Gibberellins
Herbicides
Heterocyclic compounds
Melanin
Melanins
Production processes
Review
Salt
Scaffolds
Sodium
Structure-Activity Relationship
Sulfur
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Summary:The 1,2,3-dithiazole is an underappreciated scaffold in medicinal chemistry despite possessing a wide variety of nascent pharmacological activities. The scaffold has a potential wealth of opportunities within these activities and further afield. The 1,2,3-dithiazole scaffold has already been reported as an antifungal, herbicide, antibacterial, anticancer agent, antiviral, antifibrotic, and is a melanin and Arabidopsis gibberellin 2-oxidase inhibitor. These structure activity relationships are discussed in detail, along with insights and future directions. The review also highlights selected synthetic strategies developed towards the 1,2,3-dithiazole scaffold, how these are integrated to accessibility of chemical space, and to the prism of current and future biological activities.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28073193