Nigella sativa as an anti-inflammatory agent in asthma

Nigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol...

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Bibliographic Details
Published in:BMC research notes 2018-10, Vol.11 (1), p.744-5, Article 744
Main Authors: Ikhsan, Mukhtar, Hiedayati, Nurul, Maeyama, Kazutaka, Nurwidya, Fariz
Format: Article
Language:English
Subjects:
Analgesics
Animals
Anti-inflammatory
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Antidiabetics
Antioxidants
Asthma
Asthma - drug therapy
Asthma - prevention & control
Bronchodilators
Cancer
Cytokines
Diabetes mellitus
Ethanol
Fluorometry
High-performance liquid chromatography
Histamine
Histamine - metabolism
Inflammation
Mast cells
Mast Cells - drug effects
Medical research
Nigella sativa
Peritoneal Cavity
Peritoneum
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Rats
Rats, Wistar
Research Note
Seeds
Tumor necrosis factor-TNF
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Summary:Nigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The laboratory experiment was used to investigate the effectivity of N. sativa as an anti-inflammatory on mast cells. Six groups of mast cells were stimulated by C 48/80 to release histamine. Group 1 were without N. sativa, while group 2, 3, 4, 5, and 6 were given N. sativa with concentrations of 0.1 mg/ml, 0.2 mg/ml, 0.3 mg/ml, 0.4 mg/ml and 0.5 mg/ml, respectively. Histamine concentration was measured by high-performance liquid chromatography-fluorometry. The study showed that N. sativa ethanol extract effectively inhibit histamine release from peritoneal Wistar rat mast cells proportionally to its concentration. N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. N. sativa could be considered as a potential therapy for asthma therapy and prevention.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-018-3858-8