Antidepressant pathways of the Chinese herb jiaweisinisan through genetic ontology analysis

Active compounds and corresponding targets of the traditional Chinese herb, were obtained from systems pharmacological database and placed into ClueGO for gene ontology analysis. The targets of depression were obtained from the Online Mendelian Inheritance in Man, the Therapeutic Target Database, an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of integrative neuroscience 2020-06, Vol.19 (2), p.385-395
Main Authors: Chen, Jie, Huang, Yunling, Li, Ling, Niu, Jie, Ye, Weiqiong, Wang, Yunnan, Yan, Can, Wu, Lili
Format: Article
Language:English
Subjects:
Antidepressive Agents - pharmacology
Drugs, Chinese Herbal - pharmacology
Gene Ontology
Humans
Pharmacogenetics
Phytotherapy
systems neuropharmacology|gene ontology|depression|neuroinformatics|neurogenetics|antidepressant mechanisms|traditional chinese herbs
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Active compounds and corresponding targets of the traditional Chinese herb, were obtained from systems pharmacological database and placed into ClueGO for gene ontology analysis. The targets of depression were obtained from the Online Mendelian Inheritance in Man, the Therapeutic Target Database, and the Pharmacogenomics Knowledge Base. Compound-target and target-pathway networks were constructed using Cytoscape, and then their topological parameters were analyzed. The targets of and depression were mapped to pathways, thereby constructing antidepressant pathways of . It was found that has 82 different active compounds and 306 relevant potential targets. Also, 107 unrepeatable targets related to depression were found. In all, 26 common targets were found to be the direct anti-depression targets of and 9 pathways of related to depression were divided into three modules (synaptic transmission, cell apoptosis, and immune-inflammatory). The formula was found to have synergistic antidepressant effects due to aspects of its herb composition and the active compounds therein, giving rise to potential targets and signaling pathways related to depression. Its antidepressant mechanisms were found to mainly involve the regulation of synaptic transmission, cell apoptosis, and immune-mediated inflammation.
ISSN:0219-6352
1757-448X
DOI:10.31083/j.jin.2020.02.1246