Patient experience of moderate asthma attacks: qualitative research in the USA and Germany

• Published in: Journal of patient-reported outcomes 2022-11, Vol.6 (1), p.117-14, Article 117
• Main Authors: Tabberer, Maggie, Wells, Jane R., Chandler, Dale, Abetz-Webb, Linda, Zhang, Shiyuan, Meeraus, Wilhelmine, Fowler, Andy, Slade, David
• Format: Article
• Language: English
• Subjects: Asthma; Concept elicitation; Impact; Medicine; Medicine & Public Health; Moderate asthma exacerbation; Patients; Qualitative research; Quality of Life Research; Symptoms; Treatment
• ISSN: 2509-8020; 2509-8020
• DOI: 10.1186/s41687-022-00506-2

Background There is limited information available on the impact of moderate asthma exacerbations, often called “asthma attacks” (i.e., those not requiring hospitalisation or treatment with systemic corticosteroids) on patients’ lives. This multi-country qualitative study explored the patient experience of these events. Methods Semi-structured concept elicitation interviews were conducted in the USA and Germany with adult patients with asthma who had experienced a moderate asthma exacerbation in the prior 30 days. Physicians with experience in managing patients with asthma were also interviewed. Interviews explored patients’ experience of symptoms and impact of moderate exacerbations and associated exacerbation triggers and treatment patterns. Physicians were also asked about their interpretation of a clinical definition and treatment of a moderate exacerbation. Results Twenty-eight patient (n = 20 in the USA, n = 8 in Germany) and six physician (n = 3 in the USA, n = 3 in Germany) interviews were conducted. During their moderate exacerbation, all patients reported experiencing shortness of breath, which many considered to be severe and the most bothersome symptom. Wheezing was also reported by all patients and considered severe by two thirds of patients. Most patients also reported coughing and chest tightness. All or almost all patients reported that moderate exacerbation caused fatigue/tiredness and impacted their physical functioning, emotional functioning, activities of daily living and work/school life. Most patients reported using rescue or maintenance inhalers to alleviate symptoms of the exacerbation. Conceptual saturation (i.e., the point at which no new concepts are likely to emerge with continued data collection) was achieved. Findings were used to develop a patient-focused conceptual model of the experience of moderate asthma exacerbations, outlining concepts related to triggers, symptoms, impact, and treatment from the patient perspective. Physician data was consistent with patient reports and complemented the conceptual model. Conclusions Findings from concept elicitation interviews highlight the increased frequency, duration and severity of asthma symptoms and increased rescue medication use during moderate asthma exacerbations compared with the typical daily asthma experience, which have a substantial impact on patients’ lives.