Costus speciosus leaf and seed extracts for wound healing: a comparative evaluation using mice excision wound models

Background The present study investigated the potential wound healing activity comparisons between ethanol leaf & seed extracts of Costus speciosus topical formulation using mice Excision wound models, compared to Neomycin sulphate ointment as a standard drug. To assess the efficacy of Costus sp...

Full description

Saved in:
Bibliographic Details
Published in:Clinical phytoscience 2024-12, Vol.10 (1), p.5-10, Article 5
Main Authors: Zishan, Shafiul Azam, Uddin, Md. Maien, Mohammad, Mahatir, Asadul Karim Azad, S. M., Naima, Jannatul, Ibban, Sadab Sipar, Saiful Islam Arman, Md
Format: Article
Language:English
Subjects:
Animal models
Costus speciosus
Diabetes
Effectiveness
Ethanol
Ethanolic extract
Excision wound model
Gastroenterology
Granulation
Gynecology
Leaf & seed extract
Leaves
Medicine
Medicine & Public Health
Mice wound excision
Neomycin
Ointments
Original Contribution
Pediatrics
Plant extracts
Pneumology/Respiratory System
Seeds
Sulfates
Tensile strength
Wound healing
Wound healing study
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The present study investigated the potential wound healing activity comparisons between ethanol leaf & seed extracts of Costus speciosus topical formulation using mice Excision wound models, compared to Neomycin sulphate ointment as a standard drug. To assess the efficacy of Costus speciosus ointment as a potential alternative to commercially available ointments, a study was conducted using a cohort of 16 healthy male mice, aged between 3 and 4 months. The ointment formulation was prepared utilizing ethanol extracts from both the leaves and seeds, presented in a dosage form for application. This investigation seeks to provide insights into the comparative effectiveness of Costus speciosus ointments in relation to conventional market preparations, with a focus on its potential applicability as an alternative therapeutic option. The parameter measured was wound contraction and epithelization period. Result The mice groups treated with seed & leave extracts ointment showed better wound size changes than the negative and standard groups. However, the leaf extract ointment promotes the formation of granulation in tissue, allowing the reepithelization phase to occur more rapidly than seed extract. From the 1st day to the results of the 9th day of the extract indicate that there is a significant increase ( P  
ISSN:2199-1197
2199-1197
DOI:10.1186/s40816-024-00368-9