Atopic dermatitis and cognitive dysfunction in middle-aged and older adults: A systematic review and meta-analysis

BACKGROUNDAtopic dermatitis (AD) is a common chronic inflammatory skin disease that affects adults worldwide. Recent evidence suggests that AD may be associated with cognitive dysfunction, but the results of individual studies have been inconsistent. This systematic review and meta-analysis aimed to...

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Bibliographic Details
Published in:PloS one 2023-10, Vol.18 (10), p.e0292987-e0292987
Main Authors: Zhou, Qi, Yang, Dejiang, Xiong, Chongyu, Li, Xinming
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Medicine and Health Sciences
People and Places
Physical Sciences
Research and Analysis Methods
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Summary:BACKGROUNDAtopic dermatitis (AD) is a common chronic inflammatory skin disease that affects adults worldwide. Recent evidence suggests that AD may be associated with cognitive dysfunction, but the results of individual studies have been inconsistent. This systematic review and meta-analysis aimed to evaluate the association between AD and cognitive dysfunction in middle-aged and older adults.METHODSTo find relevant research, a comprehensive search of electronic databases from the beginning to March 2023 was carried out. Data were taken from studies that were eligible, and a meta-analysis was done to determine the pooled hazard ratio (HR) and 95% confidence interval (CI).RESULTSWe searched three databases and found a total of 15 studied arms included in 5 cohort studies with over 8.5 million participants were included in the analysis. The results showed that individuals with AD had a higher risk of developing dementia of all-cause dementia (pooled hazard ratio (HR) = 1.16; 95% CI, 1.10-1.23,P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0292987