HLA Allele Frequencies and Association with Severity of COVID-19 Infection in Northern Italian Patients

HLA allelic distribution was analysed in a cohort of 96 Northern Italian subjects (53M/43F) (mean age 59.9 ± 13.3 years) from Lombardy who developed COVID-19 during the first two pandemic waves to investigate possible correlations between HLA molecules and disease severity. An important role of HLA-...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-05, Vol.11 (11), p.1792
Main Authors: Guerini, Franca Rosa, Bolognesi, Elisabetta, Lax, Agata, Bianchi, Luca Nicola Cesare, Caronni, Antonio, Zanzottera, Milena, Agliardi, Cristina, Albergoni, Maria Paola, Banfi, Paolo Innocente, Navarro, Jorge, Clerici, Mario
Format: Article
Language:English
Subjects:
Age
Alleles
Antigens
Brief Report
Comorbidity
Coronaviruses
COVID-19
Diabetes
disease severity
Gender
Gene frequency
Histocompatibility antigen HLA
HLA
Hypertension
Infections
Ostomy
Peptides
Pneumonia
Regression analysis
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:HLA allelic distribution was analysed in a cohort of 96 Northern Italian subjects (53M/43F) (mean age 59.9 ± 13.3 years) from Lombardy who developed COVID-19 during the first two pandemic waves to investigate possible correlations between HLA molecules and disease severity. An important role of HLA- B and HLA-C loci in modulating the clinical severity of COVID-19 disease was identified. In particular, the HLA-B07 supertype was observed to be associated with a significant risk for severe disease; conversely, the HLA-B27 supertype and allele played a protective role as they were associated with milder disease. These associations were confirmed after applying a multinomial regression analysis to adjust the correlation for age, gender and comorbidities with COVID-19 severity. Though the power of results is limited by the small sample size, data herein contribute to shedding light on the role played by genetic background in COVID-19 infection.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11111792