Office‐Based Blue Laser Therapy for Vocal Fold Leukoplakia: A Preliminary Report of 12 Cases

Objective To report the efficacy of office‐based blue laser therapy for vocal fold leukoplakia. Study Design A retrospective case series. Setting A tertiary care center. Methods A retrospective chart review of patients with vocal fold leukoplakia who underwent office‐based blue laser therapy between...

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Published in:OTO open : the official open access journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation 2023-04, Vol.7 (2), p.e59-n/a
Main Authors: Hamdan, Abdul‐Latif, Ghanem, Anthony, Abou Raji Feghali, Patrick, Hosri, Jad, Abi Zeid Daou, Christophe, Abou‐Rizk, Samer
Format: Article
Language:English
Subjects:
Acoustics
Biopsy
blue laser
Carbon dioxide
dysphonia
Females
Lasers
Local anesthesia
office‐based
Original Research
Otolaryngology
Pathology
Patients
Software
Statistical analysis
Surgery
vocal fold leukoplakia
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cited_by cdi_FETCH-LOGICAL-c5009-5933e146de588e4de84294417a10b74ac28be363d5447b2e39d6882e4241e3843
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creator Hamdan, Abdul‐Latif
Ghanem, Anthony
Abou Raji Feghali, Patrick
Hosri, Jad
Abi Zeid Daou, Christophe
Abou‐Rizk, Samer
description Objective To report the efficacy of office‐based blue laser therapy for vocal fold leukoplakia. Study Design A retrospective case series. Setting A tertiary care center. Methods A retrospective chart review of patients with vocal fold leukoplakia who underwent office‐based blue laser therapy between July 2019 and October 2022 was conducted. The video recordings of their laryngeal examination and their voice evaluation were analyzed before and after surgical intervention. Results A total of 10 patients, eight with unilateral disease and 2 with bilateral disease, were included in this study. In total, 12 vocal folds with leukoplakia were treated. Nine had a single session and 3 had 2 sessions due to incomplete regression of the lesion after the first laser therapy session. Following treatment, 9 regressed completely (75%) and 3 regressed partially (25%). The mean Voice Handicap Index‐10 (VHI‐10) score decreased significantly from 15.4 ± 12.9 preoperatively to 3.8 ± 2.86 after surgery (p = .023). There was a statistically significant decrease in the means of grade, roughness, breathiness, asthenia, and strain (p 
doi_str_mv 10.1002/oto2.59
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Study Design A retrospective case series. Setting A tertiary care center. Methods A retrospective chart review of patients with vocal fold leukoplakia who underwent office‐based blue laser therapy between July 2019 and October 2022 was conducted. The video recordings of their laryngeal examination and their voice evaluation were analyzed before and after surgical intervention. Results A total of 10 patients, eight with unilateral disease and 2 with bilateral disease, were included in this study. In total, 12 vocal folds with leukoplakia were treated. Nine had a single session and 3 had 2 sessions due to incomplete regression of the lesion after the first laser therapy session. Following treatment, 9 regressed completely (75%) and 3 regressed partially (25%). The mean Voice Handicap Index‐10 (VHI‐10) score decreased significantly from 15.4 ± 12.9 preoperatively to 3.8 ± 2.86 after surgery (p = .023). There was a statistically significant decrease in the means of grade, roughness, breathiness, asthenia, and strain (p &lt; .05). There was also a statistically significant decrease in the jitter and shimmer percent (p = .008 and p = .048, respectively) and a significant increase in the maximum phonation time from 9.63 ± 3.83 to 13.54 ± 5.92 seconds (p = .039). Conclusion This preliminary study indicates that office‐based blue laser therapy is an effective treatment modality for vocal fold leukoplakia.</description><identifier>ISSN: 2473-974X</identifier><identifier>EISSN: 2473-974X</identifier><identifier>DOI: 10.1002/oto2.59</identifier><identifier>PMID: 37333569</identifier><language>eng</language><publisher>United States: John Wiley &amp; Sons, Inc</publisher><subject>Acoustics ; Biopsy ; blue laser ; Carbon dioxide ; dysphonia ; Females ; Lasers ; Local anesthesia ; office‐based ; Original Research ; Otolaryngology ; Pathology ; Patients ; Software ; Statistical analysis ; Surgery ; vocal fold leukoplakia</subject><ispartof>OTO open : the official open access journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation, 2023-04, Vol.7 (2), p.e59-n/a</ispartof><rights>2023 The Authors. 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Study Design A retrospective case series. Setting A tertiary care center. Methods A retrospective chart review of patients with vocal fold leukoplakia who underwent office‐based blue laser therapy between July 2019 and October 2022 was conducted. The video recordings of their laryngeal examination and their voice evaluation were analyzed before and after surgical intervention. Results A total of 10 patients, eight with unilateral disease and 2 with bilateral disease, were included in this study. In total, 12 vocal folds with leukoplakia were treated. Nine had a single session and 3 had 2 sessions due to incomplete regression of the lesion after the first laser therapy session. Following treatment, 9 regressed completely (75%) and 3 regressed partially (25%). The mean Voice Handicap Index‐10 (VHI‐10) score decreased significantly from 15.4 ± 12.9 preoperatively to 3.8 ± 2.86 after surgery (p = .023). 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Study Design A retrospective case series. Setting A tertiary care center. Methods A retrospective chart review of patients with vocal fold leukoplakia who underwent office‐based blue laser therapy between July 2019 and October 2022 was conducted. The video recordings of their laryngeal examination and their voice evaluation were analyzed before and after surgical intervention. Results A total of 10 patients, eight with unilateral disease and 2 with bilateral disease, were included in this study. In total, 12 vocal folds with leukoplakia were treated. Nine had a single session and 3 had 2 sessions due to incomplete regression of the lesion after the first laser therapy session. Following treatment, 9 regressed completely (75%) and 3 regressed partially (25%). The mean Voice Handicap Index‐10 (VHI‐10) score decreased significantly from 15.4 ± 12.9 preoperatively to 3.8 ± 2.86 after surgery (p = .023). There was a statistically significant decrease in the means of grade, roughness, breathiness, asthenia, and strain (p &lt; .05). There was also a statistically significant decrease in the jitter and shimmer percent (p = .008 and p = .048, respectively) and a significant increase in the maximum phonation time from 9.63 ± 3.83 to 13.54 ± 5.92 seconds (p = .039). 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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Acoustics
Biopsy
blue laser
Carbon dioxide
dysphonia
Females
Lasers
Local anesthesia
office‐based
Original Research
Otolaryngology
Pathology
Patients
Software
Statistical analysis
Surgery
vocal fold leukoplakia
title Office‐Based Blue Laser Therapy for Vocal Fold Leukoplakia: A Preliminary Report of 12 Cases
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