Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma

This review provides an overview of evidence supporting the existence of distinct homeostatic and inflammatory eosinophil subpopulations in health and disease. Particular emphasis is placed on describing the phenotypic and functional roles of these eosinophil subtypes in asthma, as well as the pheno...

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Bibliographic Details
Published in:Biomedicines 2024-09, Vol.12 (9), p.2011
Main Authors: Wilson, Gabriella E, Gautam, Samir, Chupp, Geoffrey L
Format: Article
Language:English
Subjects:
Asthma
Bone marrow
Cytokines
eosinophils
Genotype & phenotype
Homeostasis
Infection
Inflammation
Inflammatory diseases
inflammatory eosinophils
interleukin-5
Interleukins
Leukocytes (eosinophilic)
Mitochondrial DNA
Pathogenesis
Phenotypes
Proteins
Recruitment
Review
Citations: Items that this one cites
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Description
Summary:This review provides an overview of evidence supporting the existence of distinct homeostatic and inflammatory eosinophil subpopulations in health and disease. Particular emphasis is placed on describing the phenotypic and functional roles of these eosinophil subtypes in asthma, as well as the phenotypic changes induced by clinical therapy with the anti-IL-5 biologic agent, mepolizumab. Improved understanding of distinct eosinophil phenotypes may enable targeting of select subpopulations in the treatment of patients with type 2 inflammatory diseases such as asthma.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12092011