Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

Exosomes are nano-sized vesicles (30-200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we inv...

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Bibliographic Details
Published in:Stem cell research & therapy 2018-07, Vol.9 (1), p.187-187, Article 187
Main Authors: Cho, Byong Seung, Kim, Jin Ock, Ha, Dae Hyun, Yi, Yong Weon
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adipose tissue-derived mesenchymal stem cells
Adipose tissues
Antigens
Atopic dermatitis
Body fat
Bone marrow
Care and treatment
CD86 antigen
Cellular therapy
Cytokines
Dermatitis
Dermatitis, Atopic - pathology
Dermatitis, Atopic - therapy
Eczema
Exosome
Exosomes
Exosomes - metabolism
Gene expression
Humans
Immunoglobulin E
Inflammation
Interleukin 23
Letter
Leukocytes (eosinophilic)
Lipids
Mast cells
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Mesenchyme
Metastases
Skin
Skin diseases
Stem cell transplantation
Stem cells
TNF inhibitors
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Description
Summary:Exosomes are nano-sized vesicles (30-200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes (ASC-exosomes) can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ASC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ASC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor-α (TNF-α) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ASC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-018-0939-5