Solvothermal Synthesis of Calcium Hydroxyapatite via Hydrolysis of Alpha-Tricalcium Phosphate in the Presence of Different Organic Additives

• Published in: Crystals (Basel) 2023-02, Vol.13 (2), p.265
• Main Authors: Karalkeviciene, Rasa, Raudonyte-Svirbutaviciene, Eva, Zarkov, Aleksej, Yang, Jen-Chang, Popov, Anatoli I., Kareiva, Aivaras
• Format: Article
• Language: English
• Subjects: Additives; Amino acids; Analysis; Aspartic acid; Atoms & subatomic particles; Calcium compounds; calcium hydroxyapatite; Calcium phosphates; Carbon; Chemical synthesis; Crystal structure; Ethylene glycol; Hydrolysis; Hydroxyapatite; Identification and classification; Methods; Morphology; organic additives; Proteins; Purity; Sodium dodecyl sulfate; solvothermal synthesis; α-tricalcium phosphate
• ISSN: 2073-4352; 2073-4352
• DOI: 10.3390/cryst13020265

In this study, the effects of sodium lauryl sulfate and various amino acids (DL-aspartic acid, dodecanedioic acid, and suberic acid) on the formation of calcium-deficient hydroxyapatite via hydrolysis of α-tricalcium phosphate (α-TCP) were investigated; moreover, a combined effect of these additives and ethylene glycol as a synthesis medium was also estimated. The hydrolysis reaction was performed in solutions containing different concentrations of additives in aqueous and mixed aqueous–organic media under solvothermal conditions. It was demonstrated that the nature and the concentration of organic additives influence the phase purity and morphology of the final product. Higher concentrations of sodium lauryl sulfate and dodecanedioic acid induced the formation of impurities in addition to hydroxyapatite, while aspartic and suberic acid did not affect the phase purity. The morphology of the samples varied from plate- to rod-like depending on the concentrations of specific organic additive.