The retina of the lab rat: focus on retinal ganglion cells and photoreceptors

Albino and pigmented rat strains are widely used in models to study retinal degeneration and to test new therapies. Here, we have summarized the main topographical and functional characteristics of the rat retina focussing on photoreceptors and retinal ganglion cells (RGCs), the beginning and end of...

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Published in:Frontiers in neuroanatomy 2022-09, Vol.16, p.994890-994890
Main Authors: Galindo-Romero, Caridad, Norte-Muñoz, María, Gallego-Ortega, Alejandro, Rodríguez-Ramírez, Kristy T., Lucas-Ruiz, Fernando, González-Riquelme, María Josefa, Vidal-Sanz, Manuel, Agudo-Barriuso, Marta
Format: Article
Language:English
Subjects:
Circadian rhythm
Diabetes
electroretinogram
Gene expression
Genetic engineering
Glaucoma
Light
melanopsin
Neuroscience
Optic nerve
Photoreceptors
Population
Retina
Retinal degeneration
Retinal ganglion cells
Topography
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Summary:Albino and pigmented rat strains are widely used in models to study retinal degeneration and to test new therapies. Here, we have summarized the main topographical and functional characteristics of the rat retina focussing on photoreceptors and retinal ganglion cells (RGCs), the beginning and end of the retinal circuitry, respectively. These neurons are very sensitive to injury and disease, and thus knowing their normal number, topography, and function is essential to accurately investigate on neuronal survival and protection.
ISSN:1662-5129
1662-5129
DOI:10.3389/fnana.2022.994890