Red ginseng dietary fiber promotes probiotic properties of Lactiplantibacillus plantarum and alters bacterial metabolism

Korean red ginseng has been widely used as an herbal medicine. Red ginseng dietary fiber (RGDF) is a residue of the processed ginseng product but still contains bioactive constituents that can be applied as prebiotics. In this study, we evaluated changes on fermentation profiles and probiotic proper...

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Published in:Frontiers in microbiology 2023-03, Vol.14, p.1139386-1139386
Main Authors: Jeon, Hyeon Ji, You, Seung-Hwan, Nam, Eoun Ho, Truong, Van-Long, Bang, Ji-Hong, Bae, Yeon-Ji, Rarison, Razanamanana H G, Kim, Sang-Kyu, Jeong, Woo-Sik, Jung, Young Hoon, Shin, Minhye
Format: Article
Language:English
Subjects:
dietary fiber
metabolomics
Microbiology
prebiotics
probiotics
red ginseng
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Summary:Korean red ginseng has been widely used as an herbal medicine. Red ginseng dietary fiber (RGDF) is a residue of the processed ginseng product but still contains bioactive constituents that can be applied as prebiotics. In this study, we evaluated changes on fermentation profiles and probiotic properties of strains that belong to family with RGDF supplementation. Metabolomic analyses were performed to understand specific mechanisms on the metabolic alteration by RGDF and to discover novel bioactive compounds secreted by the RGDF-supplemented probiotic strain. RGDF supplementation promoted short-chain fatty acid (SCFA) production, carbon source utilization, and gut epithelial adhesion of and inhibited attachment of enteropathogens. Intracellular and extracellular metabolome analyses revealed that RGDF induced metabolic alteration, especially associated with central carbon metabolism, and produced RGDF-specific metabolites secreted by , respectively. Specifically, showed decreases in intracellular metabolites of oleic acid, nicotinic acid, uracil, and glyceric acid, while extracellular secretion of several metabolites including oleic acid, 2-hydroxybutanoic acid, hexanol, and butyl acetate increased. RGDF supplementation had distinct effects on metabolism compared with fructooligosaccharide supplementation. These findings present potential applications of RGDF as prebiotics and bioactive compounds produced by RGDF-supplemented as novel postbiotic metabolites for human disease prevention and treatment.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1139386