Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice

• Published in: Brazilian journal of medical and biological research 2014-12, Vol.47 (12), p.1050-1056
• Main Authors: Shang, J L, Cheng, Q, Yang, W F, Zhang, M, Cui, Y, Wang, Y F
• Format: Article
• Language: English
• Subjects: Animals; BIOLOGY; Biomedical Sciences; Blotting, Western; Brain injuries; Brain Injuries - complications; Brain-Derived Neurotrophic Factor - metabolism; Care and treatment; Cerebral Cortex - injuries; Cerebral Decortication; Cognitive disorders; Complications and side effects; COX-1; Cyclooxygenase 1 - metabolism; Cyclooxygenase 1 - physiology; Cyclooxygenase Inhibitors - therapeutic use; Cyclooxygenases; Dinoprostone - analysis; Dinoprostone - metabolism; Disease Models, Animal; Enzyme regulation; Enzyme-Linked Immunosorbent Assay; Genetic aspects; Health aspects; Hippocampus - metabolism; Interleukin-6 - blood; Learning - drug effects; Learning and memory; Maze Learning - drug effects; MEDICINE, RESEARCH & EXPERIMENTAL; Memory Disorders - drug therapy; Memory Disorders - etiology; Memory Disorders - metabolism; Mice, Inbred C57BL; Proto-Oncogene Proteins c-sis - metabolism; Pyrazoles - therapeutic use; Recovery of Function - drug effects; Risk factors; SC560; Synaptophysin - analysis; Synaptophysin - metabolism; Traumatic brain injury
• ISSN: 0100-879X; 1414-431X; 1414-431X
• DOI: 10.1590/1414-431X20143601

People who suffer from traumatic brain injury (TBI) often experience cognitive deficits in spatial reference and working memory. The possible roles of cyclooxygenase-1 (COX-1) in learning and memory impairment in mice with TBI are far from well known. Adult mice subjected to TBI were treated with the COX-1 selective inhibitor SC560. Performance in the open field and on the beam walk was then used to assess motor and behavioral function 1, 3, 7, 14, and 21 days following injury. Acquisition of spatial learning and memory retention was assessed using the Morris water maze on day 15 post-TBI. The expressions of COX-1, prostaglandin E2 (PGE2), interleukin (IL)-6, brain-derived neurotrophic factor (BDNF), platelet-derived growth factor BB (PDGF-BB), synapsin-I, and synaptophysin were detected in TBI mice. Administration of SC560 improved performance of beam walk tasks as well as spatial learning and memory after TBI. SC560 also reduced expressions of inflammatory markers IL-6 and PGE2, and reversed the expressions of COX-1, BDNF, PDGF-BB, synapsin-I, and synaptophysin in TBI mice. The present findings demonstrated that COX-1 might play an important role in cognitive deficits after TBI and that selective COX-1 inhibition should be further investigated as a potential therapeutic approach for TBI.