Nutrigenomics and Beef Quality: A Review about Lipogenesis

The objective of the present review is to discuss the results of published studies that show how nutrition affects the expression of genes involved in lipid metabolism and how diet manipulation might change marbling and composition of fat in beef. Several key points in the synthesis of fat in cattle...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-06, Vol.17 (6), p.918-918
Main Authors: Ladeira, Marcio M, Schoonmaker, Jon P, Gionbelli, Mateus P, Dias, Júlio C O, Gionbelli, Tathyane R S, Carvalho, José Rodolfo R, Teixeira, Priscilla D
Format: Article
Language:English
Subjects:
Animals
Beef
Body fat
Cattle
Dietary Fats - pharmacology
Fatty Acids, Unsaturated - pharmacology
Gene expression
Gene Expression Regulation - drug effects
Lipid Metabolism
Lipids
Lipogenesis
Meat quality
Metabolism
Nutrigenomics - methods
PPAR
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
Red Meat - analysis
Review
SREBF1
transcription factors
Vitamins - pharmacology
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Summary:The objective of the present review is to discuss the results of published studies that show how nutrition affects the expression of genes involved in lipid metabolism and how diet manipulation might change marbling and composition of fat in beef. Several key points in the synthesis of fat in cattle take place at the molecular level, and the association of nutritional factors with the modulation of this metabolism is one of the recent targets of nutrigenomic research. Within this context, special attention has been paid to the study of nuclear receptors associated with fatty acid metabolism. Among the transcription factors involved in lipid metabolism, the peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding proteins (SREBPs) stand out. The mRNA synthesis of these transcription factors is regulated by nutrients, and their metabolic action might be potentiated by diet components and change lipogenesis in muscle. Among the options for dietary manipulation with the objective to modulate lipogenesis, the use of different sources of polyunsaturated fatty acids, starch concentrations, forage ratios and vitamins stand out. Therefore, special care must be exercised in feedlot feed management, mainly when the goal is to produce high marbling beef.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17060918