Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations

This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubil...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-06, Vol.23 (6), p.1363
Main Authors: Aithal, Gururaj C, Nayak, Usha Yogendra, Mehta, Chetan, Narayan, Reema, Gopalkrishna, Pratibha, Pandiyan, Sudharsan, Garg, Sanjay
Format: Article
Language:English
Subjects:
antimicrobial
Antimicrobial agents
Bioavailability
Carbitol
Cinnamon
computational formulation design
Computer applications
Computer Simulation
Controlled release
Diffusion
Diffusion cells
Disease
Drug delivery
Drug Delivery Systems
Drug dosages
Drug Stability
Gelation
Gels
Gum disease
Higher education
Inflammation
Microscopy, Electron, Transmission
Molecular dynamics
Molecular Dynamics Simulation
molecular simulation
nanoemulgel
Nanoemulsions
Nanostructures
Periodontitis
Periodontitis - drug therapy
Quercetin
Quercetin - pharmacokinetics
Quercetin - therapeutic use
Solubility
spontaneous emulsification
Surfactants
Thermodynamics
Viscosity
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Summary:This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubility studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and Carbitol as the surfactant-cosurfactant mixture (S ) and water as the aqueous phase containing 125 µg/200 µL of Quercetin was prepared by using spontaneous emulsification method. Nanoemulgel was prepared using 23% / poloxamer 407 as gel base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and the optimized formulation was studied for drug release using Franz vertical diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4% of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel (
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23061363