Interleukin-17 in Chronic Inflammatory Neurological Diseases

A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of blockade of IL-17 secreted by autoreactive T cells has been shown in various inflammatory diseases. Several cytokin...

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Bibliographic Details
Published in:Frontiers in immunology 2020-06, Vol.11, p.947
Main Authors: Milovanovic, Jelena, Arsenijevic, Aleksandar, Stojanovic, Bojana, Kanjevac, Tatjana, Arsenijevic, Dragana, Radosavljevic, Gordana, Milovanovic, Marija, Arsenijevic, Nebojsa
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Cell Differentiation
Chronic Disease
EAE
Humans
IL-17
Immunology
Inflammation - immunology
Inflammation - metabolism
Inflammation - physiopathology
Interleukin-17 - metabolism
ischemic brain injury
Nervous System - immunology
Nervous System - metabolism
Nervous System - physiopathology
Nervous System Diseases - immunology
Nervous System Diseases - metabolism
Nervous System Diseases - physiopathology
Phenotype
Receptors, Interleukin-17 - metabolism
Signal Transduction
Th17
Th17 Cells - immunology
Th17 Cells - metabolism
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Summary:A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of blockade of IL-17 secreted by autoreactive T cells has been shown in various inflammatory diseases. Several cytokines, whose production is affected by environmental factors, control Th17 differentiation and its maintenance in tissues during chronic inflammation. The roles of IL-17 in the pathogenesis of chronic neuroinflammatory conditions, multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), Alzheimer's disease, and ischemic brain injury are reviewed here. The role of environmental stimuli in Th17 differentiation is also summarized, highlighting the role of viral infection in the regulation of pathogenic T helper cells in EAE.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.00947