Novel Amides Derivative with Antimicrobial Activity of Piper betle var. nigra Leaves from Indonesia

var. is a tropical plant closely related to the common piper. has also been dubbed a promising source of natural antioxidants in herbal health products, antibacterial, antifungal, antimalarial, cytotoxic activity against the cancer cell lines K562 and HL-60, and antileishmanial. The aim of this stud...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-01, Vol.26 (2), p.335
Main Authors: Prasetya, Fajar, Salam, Supriatno, Rahmadani, Agung, Haikal, Kansy, Febrina, Lizma, Anshory, Hady, Arifuddin, Muhammad, Siregar, Vita Olivia, Narsa, Angga Cipta, Herman, Herman, Ahmad, Islamudin, Indriyanti, Niken, Ibrahim, Arsyik, Rusli, Rolan, Rijai, Laode, Kuncoro, Hadi
Format: Article
Language:English
Subjects:
Amides
Antimalarial agents
Antimicrobial activity
Antimicrobial agents
Antioxidants
Bacteria
Candida albicans
Cell culture
Chemical activity
Chemical compounds
Cytotoxicity
Ethanol
Fungicides
Hydrocarbons
Inoculum
Leaves
Piper betle
Piper betle var. nigra
piperenamide A
piperenamide B
Polyphenols
Streptococcus infections
Streptococcus mutans
Streptococcus sanguinis
Tropical plants
Tumor cell lines
Yeast
Yeasts
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Summary:var. is a tropical plant closely related to the common piper. has also been dubbed a promising source of natural antioxidants in herbal health products, antibacterial, antifungal, antimalarial, cytotoxic activity against the cancer cell lines K562 and HL-60, and antileishmanial. The aim of this study to observation Antimicrobial activity and isolation of chemical compound. The antimicrobial activity of extract was performed by well diffusion method against two oral pathogenic bacteria ( and ) and opportunistic pathogenic yeast ( ). The inoculum (bacterial and yeast suspension) was prepared from a 24-h culture on NB for bacterial suspension and on TSB for yeast suspension. Extraction and isolation using various method of chromatography. Isolated compounds were characterized by spectroscopic means. Our study showed antimicrobial activity from crude ethanol extract of leaves L. var. against two oral pathogenic bacteria and opportunistic pathogenic yeast with concentration 0.5% and 1%. The first report of two new amides derivatives, piperenamide A (1) and piperenamide B (2) in L. var. .
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26020335