Ectopic Lck expression in CLL demarcates intratumoral subpopulations with aberrant B-cell receptor signaling

•Ectopic Lck expression signifies interpatient and intratumoral heterogeneity in CLL.•Lck expression identifies CLL subpopulations with aberrant BCR signaling.

Saved in:
Bibliographic Details
Published in:Blood advances 2018-04, Vol.2 (8), p.877-882
Main Authors: Theofani, Efthymia, Alexis, Spyridon, Costeas, Paul, Andriopoulos, Christos, Feleskoura, Georgia, Zikos, Panagiotis, Aktypi, Anthi, Spyridonidis, Alexandros, Nika, Konstantina
Format: Article
Language:English
Subjects:
CD5 Antigens
Genetic Heterogeneity
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - metabolism
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism
Receptors, Antigen, B-Cell - metabolism
Signal Transduction
Stimulus Report
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Ectopic Lck expression signifies interpatient and intratumoral heterogeneity in CLL.•Lck expression identifies CLL subpopulations with aberrant BCR signaling.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2017015321