Immunohistochemical evidences of anticancer actions of metformin with other repurposed drug combinations and correlation with hamster fibrosarcoma tumor size

The aim was to detect and correlate anticancer effects of metformin in combinations with other repurposed drugs, already registered for other indications, which may be immediately applied and clinically investigated in oncology, reducing the time and cost of research for new cancer treatments. Immun...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2024, Vol.89 (5), p.643-656
Main Authors: Popovic, Jovan, Popovic, Dusica, Popovic, Kosta, Miljkovic, Dejan, Lalosevic, Dusan, Dolicanin, Zana, Capo, Ivan
Format: Article
Language:English
Subjects:
fibrosarcoma
hamsters
metformin
repurposed drugs
tumor markers
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Summary:The aim was to detect and correlate anticancer effects of metformin in combinations with other repurposed drugs, already registered for other indications, which may be immediately applied and clinically investigated in oncology, reducing the time and cost of research for new cancer treatments. Immunohistochemistry was performed for tumors treated by dual drug combinations containing metformin with deoxycholic acid, caffeine, itraconazole, nitroglycerin, disulfiram or diclofenac. The drugs were applied in Syrian golden hamsters (6 animals per group) with the inoculated BHK21/C13 fibrosarcoma in doses equivalent to usual human doses,
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC231203007P