Clinical significance of laryngopharyngeal reflux in patients with chronic obstructive pulmonary disease

Although chronic obstructive pulmonary disease (COPD) is closely associated with gastroesophageal reflux disease (GERD), the clinical significance of laryngopharyngeal reflux (LPR) is not fully understood in COPD. Prospective cohorts were established among 118 patients with COPD from March 2013 to J...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2015-01, Vol.10 (Issue 1), p.1343-1351
Main Authors: Jung, Young Ho, Lee, Doh Young, Kim, Dong Wook, Park, Sung Soo, Heo, Eun Young, Chung, Hee Soon, Kim, Deog Kyeom
Format: Article
Language:English
Subjects:
Aged
Care and treatment
Case-Control Studies
Cross-Sectional Studies
Development and progression
Disease Progression
Female
Gastroesophageal reflux
Health aspects
Humans
Laryngopharyngeal Reflux - diagnosis
Laryngopharyngeal Reflux - epidemiology
Laryngoscopy
Lung - physiopathology
Lung diseases, Obstructive
Male
Middle Aged
Original Research
Physiological aspects
Predictive Value of Tests
Prevalence
Prospective Studies
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Quality of life
Republic of Korea - epidemiology
Severity of Illness Index
Spirometry
Time Factors
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Summary:Although chronic obstructive pulmonary disease (COPD) is closely associated with gastroesophageal reflux disease (GERD), the clinical significance of laryngopharyngeal reflux (LPR) is not fully understood in COPD. Prospective cohorts were established among 118 patients with COPD from March 2013 to July 2014. Thirty-two age-matched and sex-matched normal controls, who had routine health check-ups during the study period, were included. Laryngopharyngeal reflux finding scores (RFS) and reflux symptom index (RSI) for LPR were subjected to association analysis with severity and acute exacerbation of COPD during the 1-year follow-up. The mean age of patients enrolled in the study was 69.2±8.8 years, with 93.2% being male. Positive RFS (>7) and RSI (>13) were observed in 51 (42.5%) and six patients (5.0%), respectively. RFS and RSI were significantly higher in patients with COPD than in normal, healthy patients (P
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S84337