Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Hollow nanoparticles are preferred over solid ones for their high loading capabilities, sustained release and low density. Hollow zein particles are susceptible to aggregation with a slight variation in the ionic strength, pH and temperature of the medium. This study was aimed to fabricate quercetin...

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Bibliographic Details
Published in:Antioxidants 2021-09, Vol.10 (9), p.1476
Main Authors: Khan, Muhammad Aslam, Zhou, Chufan, Zheng, Pu, Zhao, Meng, Liang, Li
Format: Article
Language:English
Subjects:
Antioxidants
Chitosan
coating
Coatings
Controlled release
Efficiency
Ethanol
Flavonoids
Free radicals
Heat treatments
hollow zein particle
Ionic strength
Nanoparticles
Particle size
Pectin
pH effects
Polysaccharides
Quercetin
Shelf life
Sodium
Sodium chloride
Spectrum analysis
X-ray diffraction
Zein
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Summary:Hollow nanoparticles are preferred over solid ones for their high loading capabilities, sustained release and low density. Hollow zein particles are susceptible to aggregation with a slight variation in the ionic strength, pH and temperature of the medium. This study was aimed to fabricate quercetin-loaded hollow zein particles with chitosan and pectin coating to improve their physicochemical stability. Quercetin as a model flavonoid had a loading efficiency and capacity of about 86–94% and 2.22–5.89%, respectively. Infrared and X-ray diffraction investigations revealed the interaction of quercetin with zein and the change in its physical state from crystalline to amorphous upon incorporation in the composite particles. The chitosan/pectin coating improved the stability of quercetin-loaded hollow zein particles against heat treatment, sodium chloride and in a wide range of pH. The complex coating protected quercetin that was encapsulated in hollow zein particles from free radicals in the aqueous medium and enhanced its DPPH radical scavenging ability. The entrapment of quercetin in the particles improved its storage and photochemical stability. The storage stability of entrapped quercetin was enhanced both at 25 and 45 °C in hollow zein particles coated with chitosan and pectin. Therefore, composite hollow zein particles fabricated with a combination of polysaccharides can expand their role in the encapsulation, protection and delivery of bioactive components.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10091476