Research progress of NF-κB signaling pathway and thrombosis

Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes fr...

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Bibliographic Details
Published in:Frontiers in immunology 2023-09, Vol.14, p.1257988-1257988
Main Authors: Wang, Zilong, Fang, Chucun, Yao, Mengting, Wu, Dongwen, Chen, Maga, Guo, Tianting, Mo, Jianwen
Format: Article
Language:English
Subjects:
Immunology
inflammation
miRNA
natural compounds
NF-κB signal pathway
TCM
thrombosis
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Summary:Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes from venous thrombosis, which is the most serious cause of death, second only to ischemic heart disease and stroke patients. It can be seen that deep-vein thrombosis has become a serious disease affecting human health. In recent years, with the deepening of research, inflammatory response is considered to be an important pathway to trigger venous thromboembolism, in which the transcription factor NF-κB is the central medium of inflammation, and the NF-κB signaling pathway can regulate the pro-inflammatory and coagulation response. Thus, to explore the mechanism and make use of it may provide new solutions for the prevention and treatment of thrombosis.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1257988