Long-term, low-dose tigecycline to treat relapsing bloodstream infection due to KPC-producing Klebsiella pneumoniae after major hepatic surgery

Highlights • KPC- Klebsiella pneumoniae biliary infection after hepatic surgery is reported. • Combination therapy failed to provide source control, and bacteraemia relapsed. • A low-dose, long-term regimen of tigecycline was administered. • Six months after the end of treatment the patient was clin...

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Bibliographic Details
Published in:International journal of infectious diseases 2015-07, Vol.36 (C), p.4-5
Main Authors: Morelli, Luca, Tartaglia, Dario, Furbetta, Niccolò, Palmeri, Matteo, Ferranti, Simone, Tagliaferri, Enrico, Di Candio, Giulio, Mosca, Franco
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Bacteremia - drug therapy
Bacterial Proteins - biosynthesis
beta-Lactamases - biosynthesis
Hepatectomy
Humans
Infectious Disease
Klebsiella Infections - drug therapy
Klebsiella pneumoniae
Klebsiella pneumoniae - enzymology
Liver - surgery
Long-term therapy
Male
Minocycline - administration & dosage
Minocycline - analogs & derivatives
Minocycline - therapeutic use
Postoperative Complications - drug therapy
Pulmonary/Respiratory
Tigecycline
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Summary:Highlights • KPC- Klebsiella pneumoniae biliary infection after hepatic surgery is reported. • Combination therapy failed to provide source control, and bacteraemia relapsed. • A low-dose, long-term regimen of tigecycline was administered. • Six months after the end of treatment the patient was clinically infection-free. • Tigecycline might be effective as a suppressive treatment in biliary infections.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.05.001