Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil

The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. Cry...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2019-01, Vol.52, p.e20180376-e20180376
Main Authors: Diniz, Alena Mileo Monteiro, Feio, Danielle Cristinne Azevedo, Silva, Aniel de Sarom Negrão, Burbano, Rommel Rodríguez, Lima, Patrícia Danielle Lima de
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brazil - epidemiology
Cerebrospinal fluid
Cryptococcal meningitis
Cryptococcus neoformans - genetics
Cryptococcus neoformans - isolation & purification
Female
Genetic polymorphisms
Genotype
Humans
Male
Meningitis, Cryptococcal - cerebrospinal fluid
Meningitis, Cryptococcal - epidemiology
Meningitis, Cryptococcal - genetics
Polymorphism, Genetic
Prevalence
TNFα
TROPICAL MEDICINE
Tumor Necrosis Factor-alpha - genetics
Young Adult
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Summary:The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found. No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0376-2018