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Biocompatible pH-Degradable Functional Capsules Based on Melamine Cyanurate Self-Assembly

Development of adaptive self-regulating materials and chemical–biological systemsself-healing, self-regulating, etc.is an advanced modern trend. The very sensitive pH-controlled functionality of supramolecular assemblies is a very useful tool for chemical and biochemical implementations. However,...

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Bibliographic Details
Published in:ACS omega 2021-07, Vol.6 (27), p.17267-17275
Main Authors: Imoro, Nfayem, Shilovskikh, Vladimir V, Nesterov, Pavel V, Timralieva, Alexandra A, Gets, Dmitry, Nebalueva, Anna, Lavrentev, Filipp V, Novikov, Alexander S, Kondratyuk, Nikolay D, Orekhov, Nikita D, Skorb, Ekaterina V
Format: Article
Language:English
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Summary:Development of adaptive self-regulating materials and chemical–biological systemsself-healing, self-regulating, etc.is an advanced modern trend. The very sensitive pH-controlled functionality of supramolecular assemblies is a very useful tool for chemical and biochemical implementations. However, the assembly process can be tuned by various factors that can be used for both better functionality control and further functionalization such as active species, e.g., drugs and dyes, and encapsulation. Here, the effect of a dye, sodium fluorescein (uranine) (FL), on the formation of a self-assembled melamine cyanurate (M–CA) structure is investigated and calculated with density functional theory (DFT) and molecular dynamics. Interestingly, the dye greatly affects the self-assembly process at early stages from the formation of dimers, trimers, and tetramer to nucleation control. The supramolecular structure disassembly and subsequent release of trapped dye occurred under both high- and low-pH conditions. This system can be used for time-prolonged bacterial staining and development of supramolecular capsules for the system chemistry approach.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.1c01124