Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes

Away from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects included chronic intravenous heroin addicts and control subjects. Hematological...

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Bibliographic Details
Published in:Journal of toxicology 2022-09, Vol.2022, p.1-7
Main Authors: Bani-Ahmad, Mohammad A., Mustafa, Ayman G., Bani Ahmad, Abdelraheem A., Alkhazali, Islam E., Rahim, Ahmad A.
Format: Article
Language:English
Subjects:
Addictions
Addicts
Analysis
Blood tests
Carbonyl compounds
Carbonyls
Chronic illnesses
Correlation analysis
Drug abuse
Drug addiction
Drug addicts
Drug dosages
Erythrocytes
Ethylenediaminetetraacetic acid
Glutathione
Glutathione peroxidase
Hematology
Hemoglobin
Heroin
Intravenous administration
Methemoglobin
Morphology
Narcotics
Peroxidase
Pharmacokinetics
Physiology
Proteins
Turnover rate
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Summary:Away from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects included chronic intravenous heroin addicts and control subjects. Hematological analysis and redox parameters were measured, including serum concentration of methemoglobin ([MethHb]), serum glutathione peroxidase-1 ([GPX-1]), serum glutathione peroxidase (GPX) activity, erythrocytic protein carbonyl content, and oxidized to reduced glutathione (GSSG/GSH) ratio. Hematological analysis revealed that addicts had a significantly higher red cell distribution width, consistent with the mild anisocytosis and poikilocytosis of erythrocytes. As compared to control subjects, significantly higher levels of serum [Met-Hb], [GPX-1], and GPX activity (p
ISSN:1687-8191
1687-8205
DOI:10.1155/2022/3996051