Association Between Self-Rated Medication Adherence and Adverse Cardiovascular Outcomes in Patients With Hypertension

Medication nonadherence contributes to poor health outcomes but remains challenging to identify. This study assessed the association between self-rated adherence and systolic blood pressure, low-density lipoprotein cholesterol levels, cardiovascular events, and all-cause mortality in SPRINT (Systoli...

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Bibliographic Details
Published in:Journal of the American Heart Association 2023-11, Vol.12 (22), p.e031418
Main Authors: Ibrahim, Shirin, Nurmohamed, Nick S, Collard, Didier, de Weger, Anouk, Hovingh, G Kees, van den Born, Bert-Jan H, Reeskamp, Laurens F, Stroes, Erik S G, Brouwer, Tom F
Format: Article
Language:English
Subjects:
adverse cardiovascular outcomes
Aged
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
blood pressure
Blood Pressure - drug effects
Cardiovascular Diseases - mortality
Cause of Death - trends
Cholesterol, LDL - blood
Female
Humans
Hypertension - drug therapy
Hypertension - physiopathology
LDL cholesterol
Male
medication adherence
Medication Adherence - statistics & numerical data
Middle Aged
Original Research
Proportional Hazards Models
Risk Factors
Self Report
Time Factors
Treatment Outcome
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Summary:Medication nonadherence contributes to poor health outcomes but remains challenging to identify. This study assessed the association between self-rated adherence and systolic blood pressure, low-density lipoprotein cholesterol levels, cardiovascular events, and all-cause mortality in SPRINT (Systolic Blood Pressure Intervention Trial). A total of 9361 patients randomized to 2 systolic blood pressure target groups,
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.123.031418