Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. The particle technology involves several approaches from the conve...

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Bibliographic Details
Published in:Asian journal of pharmceutical sciences 2014-12, Vol.9 (6), p.304-316
Main Authors: Khadka, Prakash, Ro, Jieun, Kim, Hyeongmin, Kim, Iksoo, Kim, Jeong Tae, Kim, Hyunil, Cho, Jae Min, Yun, Gyiae, Lee, Jaehwi
Format: Article
Language:English
Subjects:
Dissolution
Drug solubility
Particle technology
Poorly water soluble drug
Solubility enhancement
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Summary:Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. The particle technology involves several approaches from the conventional size reduction processes to the newer, novel particle technologies that modify the solubility properties of the drugs and produce solid, powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms. This review highlights the solid particle technologies available for improving solubility, dissolution and bioavailability of drugs with poor aqueous solubility.
ISSN:1818-0876
2221-285X
DOI:10.1016/j.ajps.2014.05.005