Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology

In humans, hantaviruses can cause haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). Currently it is estimated that 150,000 to 200,000 cases of hantavirus disease occur each year, the majority being reported in Asia. However, human hantavirus infections are...

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Bibliographic Details
Published in:Swiss medical weekly 2014-03, Vol.144 (1112), p.w13937-w13937
Main Authors: Manigold, Tobias, Vial, Pablo
Format: Article
Language:English
Subjects:
Animals
Hantavirus
Hantavirus Pulmonary Syndrome - diagnosis
Hantavirus Pulmonary Syndrome - drug therapy
Hantavirus Pulmonary Syndrome - epidemiology
Hantavirus Pulmonary Syndrome - immunology
HCPS
Hemorrhagic Fever with Renal Syndrome - diagnosis
Hemorrhagic Fever with Renal Syndrome - drug therapy
Hemorrhagic Fever with Renal Syndrome - epidemiology
Hemorrhagic Fever with Renal Syndrome - immunology
HFRS
Humans
immunology
pathogenesis
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Summary:In humans, hantaviruses can cause haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). Currently it is estimated that 150,000 to 200,000 cases of hantavirus disease occur each year, the majority being reported in Asia. However, human hantavirus infections are increasingly reported in the Americas and Europe. Although many of the underlying pathogenic mechanisms still remain unclear, recent evidence rather argues against a purely immune-mediated pathophysiology of human disease. Despite the high morbidity and case-fatality rates of HFRS and HCPS, respectively, no vaccine or drug is currently proven to be preventive or therapeutic. This review summarises clinical features and current epidemiological findings, as well as concepts regarding the immunology, pathogenesis and intervention strategies of human hantaviral diseases.
ISSN:1424-7860
1424-3997
DOI:10.4414/smw.2014.13937