Semisynthesis and Pesticidal Activities of Novel Cholesterol Ester Derivatives Containing Cinnamic Acid-like Fragments

Due to the extensive use of agrochemicals resulting in the emergence of pesticide resistance and ecological environment problems, the research and development of new alternatives for crop protection is highly desirable. In order to discover potent natural product-based insecticide candidates, a seri...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.27 (23), p.8437
Main Authors: Lu, Rongfei, Xu, Jianwei, Wang, Zhen, Zhang, Shaoyong, Wang, Hailong, Xu, Hui, Lv, Min
Format: Article
Language:English
Subjects:
Acids
agricultural activity
Agricultural chemicals
Agricultural production
Agrochemicals
Animals
Cholesterol
Cholesterol Esters
Chromatography
Cinnamic acid
Ecological effects
Fragments
Immunoglobulins
Insecticide resistance
Insecticides
Insecticides - chemistry
Molecular Structure
Moths
Natural products
Pesticide resistance
Pesticides
Pesticides - pharmacology
Plant protection
R&D
Research & development
Semisynthesis
structural modification
Structure-Activity Relationship
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Summary:Due to the extensive use of agrochemicals resulting in the emergence of pesticide resistance and ecological environment problems, the research and development of new alternatives for crop protection is highly desirable. In order to discover potent natural product-based insecticide candidates, a series of new cholesterol ester derivatives containing cinnamic acid-like fragments at the C-7 position were synthesized. Some derivatives showed potent pesticidal activities. Against Walker, compounds , , , and showed 2.1-2.4-fold growth-inhibitory activity of the precursor cholesterol. Against Linnaeus, compounds , , and exhibited 1.9-2.1-fold insecticidal activity of cholesterol. These results will pave the way for the future synthesis of cholesterol-based derivatives as agrochemicals.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238437