Wilms' tumor gene 1 is an independent prognostic factor for pediatric acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation

• Published in: BMC cancer 2021-03, Vol.21 (1), p.292-292, Article 292
• Main Authors: Deng, Dao-Xing, Wen, Juan-Juan, Cheng, Yi-Fei, Zhang, Xiao-Hui, Xu, Lan-Ping, Wang, Yu, Yan, Chen-Hua, Chen, Yu-Hong, Chen, Huan, Han, Wei, Wang, Feng-Rong, Wang, Jing-Zhi, Qin, Ya-Zhen, Liu, Kai-Yan, Huang, Xiao-Jun, Zhao, Xiao-Su, Mo, Xiao-Dong
• Format: Article
• Language: English
• Subjects: Acute myeloid leukemia; Adolescent; Allogeneic hematopoietic stem cell transplantation; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Bone Marrow - pathology; Cancer in children; Care and treatment; Chemotherapy; Child; Child, Preschool; Disease-Free Survival; Female; Genetic aspects; Hematology; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Humans; Immunotherapy; Incidence; Infant; Intervention; Kaplan-Meier Estimate; Leukemia; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - pathology; Leukemia, Myeloid, Acute - therapy; Male; Minimal residual disease; Myeloid leukemia; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasm, Residual; Patient outcomes; Patients; Pediatric; Pediatric research; Pediatrics; Polymerase chain reaction; Prognosis; Relapse; Reverse transcription; Risk Assessment - methods; Risk factors; Software; Stem cell transplantation; Stem cells; Transplantation; Transplantation, Homologous; Transplants & implants; Tumor suppressor genes; Wilms’ tumor gene 1; WT1 Proteins - analysis; WT1 Proteins - metabolism; α-Interferon
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-021-08022-0

Sequential monitoring of Wilms' tumor gene 1 (WT1) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) could predict relapse in adult acute myeloid leukemia (AML). However, the prognostic role of WT1 in pediatric AML after allo-HSCT is unclear. Thus, we determined to see whether sequential monitoring of WT1 after allo-HSCT could predict relapse in AML children. Pediatric AML patients receiving allo-HSCT from January 21, 2012 to December 20, 2018 at the Peking University Institute of Hematology were included in this study. WT1 expression level was determined by TaqMan-based reverse transcription-polymerase chain reaction. WT1 sequential monitoring was performed 1, 2, 3, 4.5, 6, 9, and 12 months post-transplantation and at 6-month intervals thereafter. The primary end point was relapse. The secondary end points included disease-free survival (DFS), overall survival (OS), and non-relapse mortality (NRM). Kaplan-Meier analysis was used for DFS and OS estimates, while competing risk analysis was used for estimating relapse and NRM. Of the 151 consecutive patients included, the median age was 10 years (range, 1-17). The optimal cutoff value of WT1 within 1 year after allo-HSCT to predict relapse was 0.8% (80 WT1 copies/10 ABL copies), with a sensitivity of 60% and specificity of 79%. Compared with WT1 expression