The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa....

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes research 2020, Vol.2020 (2020), p.1-16
Main Authors: Floria, Mariana, Maranduca, Minela Aida, Lacatusu, Cristina Mihaela, Ciocoiu, Manuela, Costea, Claudia Florida, Gosav, Evelina Maria, Tanase, Daniela-Maria, Ouatu, Anca
Format: Article
Language:English
Subjects:
Apoptosis
Diabetes
Fatty acids
Gene expression
Glucose
Glycerol
Homeostasis
Inflammation
Insulin resistance
Kinases
Lipid peroxidation
Lipids
Liver diseases
Metabolic disorders
Metabolic syndrome
Obesity
Oxidation
Oxidative stress
Proteins
Review
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
ISSN:2314-6745
2314-6753
DOI:10.1155/2020/3920196