The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa....

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes research 2020, Vol.2020 (2020), p.1-16
Main Authors: Floria, Mariana, Maranduca, Minela Aida, Lacatusu, Cristina Mihaela, Ciocoiu, Manuela, Costea, Claudia Florida, Gosav, Evelina Maria, Tanase, Daniela-Maria, Ouatu, Anca
Format: Article
Language:English
Subjects:
Apoptosis
Diabetes
Fatty acids
Gene expression
Glucose
Glycerol
Homeostasis
Inflammation
Insulin resistance
Kinases
Lipid peroxidation
Lipids
Liver diseases
Metabolic disorders
Metabolic syndrome
Obesity
Oxidation
Oxidative stress
Proteins
Review
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843
cites cdi_FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843
container_end_page 16
container_issue 2020
container_start_page 1
container_title Journal of diabetes research
container_volume 2020
creator Floria, Mariana
Maranduca, Minela Aida
Lacatusu, Cristina Mihaela
Ciocoiu, Manuela
Costea, Claudia Florida
Gosav, Evelina Maria
Tanase, Daniela-Maria
Ouatu, Anca
description Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
doi_str_mv 10.1155/2020/3920196
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_5534b2bacae74a2dba72bf5cc5ba90ef</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_5534b2bacae74a2dba72bf5cc5ba90ef</doaj_id><sourcerecordid>2436876038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843</originalsourceid><addsrcrecordid>eNqFkt9r2zAQgM3YWEvXtz0PwV5S1qz6aUsvg9IsWyDtoGTP4iyfGwXHyiy7JX_C_uupdejoXiYEOu6--xDHZdl7Rj8zptQFp5xeCMMpM_mr7JgLJqd5ocTr51iqo-w0xg1NxwijlX6bHQmuBVc5Pc5-r9ZIFm3feQc9kltsoPehjWu_IyX2D4gtWe13SDiZeUgZjOQam8b3QySTFZ9dn52n_jg0vk3d0cceWodksrhNBWgrchNaaFxYh8Y7Moe-35Olv8cu-SJCTOjN5Xw5O3uXvamhiXh6eE-yn_Ovq6vv0-WPb4ury-XU5Yz1Uy5Kg7rUGkBrmZtKlLxm0ghHVbpCFVwimlQU4EAYhUJXzLm8okwbLcVJthi9VYCN3XV-C93eBvD2KRG6Owtd712DVikhS14mDxYSeFVCwctaOadKMBTr5PoyunZDucXKYRokNC-kLyutX9u7cG8LyaU0LAkmB0EXfg0Ye7v10aX5QothiJZLkesip0In9OM_6CYMXZrtEyWlpKYQiTofKdeFGDusnz_DqH1cGfu4MvawMgn_NOJr31bw4P9HfxhpTAzW8JdmWlDNxB-Nbcb8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2434440973</pqid></control><display><type>article</type><title>The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)</title><source>PubMed Central (Open Access)</source><source>Wiley-Blackwell Open Access Collection</source><source>Publicly Available Content Database</source><creator>Floria, Mariana ; Maranduca, Minela Aida ; Lacatusu, Cristina Mihaela ; Ciocoiu, Manuela ; Costea, Claudia Florida ; Gosav, Evelina Maria ; Tanase, Daniela-Maria ; Ouatu, Anca</creator><contributor>Jia, Guanghong ; Guanghong Jia</contributor><creatorcontrib>Floria, Mariana ; Maranduca, Minela Aida ; Lacatusu, Cristina Mihaela ; Ciocoiu, Manuela ; Costea, Claudia Florida ; Gosav, Evelina Maria ; Tanase, Daniela-Maria ; Ouatu, Anca ; Jia, Guanghong ; Guanghong Jia</creatorcontrib><description>Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.</description><identifier>ISSN: 2314-6745</identifier><identifier>EISSN: 2314-6753</identifier><identifier>DOI: 10.1155/2020/3920196</identifier><identifier>PMID: 32832560</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Diabetes ; Fatty acids ; Gene expression ; Glucose ; Glycerol ; Homeostasis ; Inflammation ; Insulin resistance ; Kinases ; Lipid peroxidation ; Lipids ; Liver diseases ; Metabolic disorders ; Metabolic syndrome ; Obesity ; Oxidation ; Oxidative stress ; Proteins ; Review ; Tumor necrosis factor-TNF</subject><ispartof>Journal of diabetes research, 2020, Vol.2020 (2020), p.1-16</ispartof><rights>Copyright © 2020 Daniela Maria Tanase et al.</rights><rights>Copyright © 2020 Daniela Maria Tanase et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2020 Daniela Maria Tanase et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843</citedby><cites>FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843</cites><orcidid>0000-0003-1730-9306 ; 0000-0001-8923-8194 ; 0000-0002-7144-2506 ; 0000-0002-9465-1503 ; 0000-0002-9240-2175</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2434440973/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2434440973?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4022,25752,27922,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids></links><search><contributor>Jia, Guanghong</contributor><contributor>Guanghong Jia</contributor><creatorcontrib>Floria, Mariana</creatorcontrib><creatorcontrib>Maranduca, Minela Aida</creatorcontrib><creatorcontrib>Lacatusu, Cristina Mihaela</creatorcontrib><creatorcontrib>Ciocoiu, Manuela</creatorcontrib><creatorcontrib>Costea, Claudia Florida</creatorcontrib><creatorcontrib>Gosav, Evelina Maria</creatorcontrib><creatorcontrib>Tanase, Daniela-Maria</creatorcontrib><creatorcontrib>Ouatu, Anca</creatorcontrib><title>The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)</title><title>Journal of diabetes research</title><description>Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.</description><subject>Apoptosis</subject><subject>Diabetes</subject><subject>Fatty acids</subject><subject>Gene expression</subject><subject>Glucose</subject><subject>Glycerol</subject><subject>Homeostasis</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver diseases</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Obesity</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Review</subject><subject>Tumor necrosis factor-TNF</subject><issn>2314-6745</issn><issn>2314-6753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqFkt9r2zAQgM3YWEvXtz0PwV5S1qz6aUsvg9IsWyDtoGTP4iyfGwXHyiy7JX_C_uupdejoXiYEOu6--xDHZdl7Rj8zptQFp5xeCMMpM_mr7JgLJqd5ocTr51iqo-w0xg1NxwijlX6bHQmuBVc5Pc5-r9ZIFm3feQc9kltsoPehjWu_IyX2D4gtWe13SDiZeUgZjOQam8b3QySTFZ9dn52n_jg0vk3d0cceWodksrhNBWgrchNaaFxYh8Y7Moe-35Olv8cu-SJCTOjN5Xw5O3uXvamhiXh6eE-yn_Ovq6vv0-WPb4ury-XU5Yz1Uy5Kg7rUGkBrmZtKlLxm0ghHVbpCFVwimlQU4EAYhUJXzLm8okwbLcVJthi9VYCN3XV-C93eBvD2KRG6Owtd712DVikhS14mDxYSeFVCwctaOadKMBTr5PoyunZDucXKYRokNC-kLyutX9u7cG8LyaU0LAkmB0EXfg0Ye7v10aX5QothiJZLkesip0In9OM_6CYMXZrtEyWlpKYQiTofKdeFGDusnz_DqH1cGfu4MvawMgn_NOJr31bw4P9HfxhpTAzW8JdmWlDNxB-Nbcb8</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Floria, Mariana</creator><creator>Maranduca, Minela Aida</creator><creator>Lacatusu, Cristina Mihaela</creator><creator>Ciocoiu, Manuela</creator><creator>Costea, Claudia Florida</creator><creator>Gosav, Evelina Maria</creator><creator>Tanase, Daniela-Maria</creator><creator>Ouatu, Anca</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1730-9306</orcidid><orcidid>https://orcid.org/0000-0001-8923-8194</orcidid><orcidid>https://orcid.org/0000-0002-7144-2506</orcidid><orcidid>https://orcid.org/0000-0002-9465-1503</orcidid><orcidid>https://orcid.org/0000-0002-9240-2175</orcidid></search><sort><creationdate>2020</creationdate><title>The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)</title><author>Floria, Mariana ; Maranduca, Minela Aida ; Lacatusu, Cristina Mihaela ; Ciocoiu, Manuela ; Costea, Claudia Florida ; Gosav, Evelina Maria ; Tanase, Daniela-Maria ; Ouatu, Anca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Diabetes</topic><topic>Fatty acids</topic><topic>Gene expression</topic><topic>Glucose</topic><topic>Glycerol</topic><topic>Homeostasis</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver diseases</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Obesity</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Review</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Floria, Mariana</creatorcontrib><creatorcontrib>Maranduca, Minela Aida</creatorcontrib><creatorcontrib>Lacatusu, Cristina Mihaela</creatorcontrib><creatorcontrib>Ciocoiu, Manuela</creatorcontrib><creatorcontrib>Costea, Claudia Florida</creatorcontrib><creatorcontrib>Gosav, Evelina Maria</creatorcontrib><creatorcontrib>Tanase, Daniela-Maria</creatorcontrib><creatorcontrib>Ouatu, Anca</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of diabetes research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Floria, Mariana</au><au>Maranduca, Minela Aida</au><au>Lacatusu, Cristina Mihaela</au><au>Ciocoiu, Manuela</au><au>Costea, Claudia Florida</au><au>Gosav, Evelina Maria</au><au>Tanase, Daniela-Maria</au><au>Ouatu, Anca</au><au>Jia, Guanghong</au><au>Guanghong Jia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)</atitle><jtitle>Journal of diabetes research</jtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>2314-6745</issn><eissn>2314-6753</eissn><abstract>Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32832560</pmid><doi>10.1155/2020/3920196</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-1730-9306</orcidid><orcidid>https://orcid.org/0000-0001-8923-8194</orcidid><orcidid>https://orcid.org/0000-0002-7144-2506</orcidid><orcidid>https://orcid.org/0000-0002-9465-1503</orcidid><orcidid>https://orcid.org/0000-0002-9240-2175</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6745
ispartof Journal of diabetes research, 2020, Vol.2020 (2020), p.1-16
issn 2314-6745
2314-6753
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_5534b2bacae74a2dba72bf5cc5ba90ef
source PubMed Central (Open Access); Wiley-Blackwell Open Access Collection; Publicly Available Content Database
subjects Apoptosis
Diabetes
Fatty acids
Gene expression
Glucose
Glycerol
Homeostasis
Inflammation
Insulin resistance
Kinases
Lipid peroxidation
Lipids
Liver diseases
Metabolic disorders
Metabolic syndrome
Obesity
Oxidation
Oxidative stress
Proteins
Review
Tumor necrosis factor-TNF
title The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T21%3A04%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Intricate%20Relationship%20between%20Type%202%20Diabetes%20Mellitus%20(T2DM),%20Insulin%20Resistance%20(IR),%20and%20Nonalcoholic%20Fatty%20Liver%20Disease%20(NAFLD)&rft.jtitle=Journal%20of%20diabetes%20research&rft.au=Floria,%20Mariana&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=16&rft.pages=1-16&rft.issn=2314-6745&rft.eissn=2314-6753&rft_id=info:doi/10.1155/2020/3920196&rft_dat=%3Cproquest_doaj_%3E2436876038%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c611t-23b9e8b88aa88469d3b2f1493c05c0535724ee9a883aca395e38d1cc6d0189843%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2434440973&rft_id=info:pmid/32832560&rfr_iscdi=true