Endothelial dysfunction and preeclampsia: role of oxidative stress

Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5-10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and m...

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Bibliographic Details
Published in:Frontiers in physiology 2014, Vol.5, p.372-372
Main Authors: Sánchez-Aranguren, Lissette C, Prada, Carlos E, Riaño-Medina, Carlos E, Lopez, Marcos
Format: Article
Language:English
Subjects:
endothelial dysfunction
Nitric Oxide
Oxidative Stress
Physiology
Preeclampsia
Reactive Oxygen Species
superoxide
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Summary:Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5-10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The related poor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2014.00372