Norepinephrine titration in patients with sepsis-induced encephalopathy: cerebral pulsatility index compared to mean arterial pressure guided protocol: randomized controlled trial

Although surviving sepsis campaign (SSC) guidelines are the standard for sepsis and septic shock management, outcomes are still unfavourable. Given that perfusion pressure in sepsis is heterogeneous among patients and within the same patient; we evaluated the impact of individualized hemodynamic man...

Full description

Saved in:
Bibliographic Details
Published in:BMC anesthesiology 2025-01, Vol.25 (1), p.5-10, Article 5
Main Authors: Salem, Mai Salah, Abosabaa, Motaz Amr, Abd El Ghafar, Mohamed Samir, Ei-Gendy, Hala Mohey Ei-Deen Mohamed, Alsherif, Salah El-Din Ibrahim
Format: Article
Language:English
Subjects:
Blood pressure
Bradycardia
Care and treatment
Carotid arteries
Cerebral hypoperfusion
Clinical trials
Dosage
Encephalopathy
Flow velocity
Health aspects
Heart beat
Heart rate
Hemodynamics
Hypotension
ICU mortality
Infection
Infections
Lactates
Lactic acid
Mean arterial pressure
Medical research
Medicine, Experimental
Mortality
Noradrenaline
Norepinephrine
Norepinephrine titration
Patients
Perfusion
Sepsis
Sepsis-induced encephalopathy
Septic shock
Statistical analysis
Tachycardia
TCD Pulsatility index
Titration
Ultrasonic imaging
Ultrasound
Veins & arteries
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although surviving sepsis campaign (SSC) guidelines are the standard for sepsis and septic shock management, outcomes are still unfavourable. Given that perfusion pressure in sepsis is heterogeneous among patients and within the same patient; we evaluated the impact of individualized hemodynamic management via the transcranial Doppler (TCD) pulsatility index (PI) on mortality and outcomes among sepsis-induced encephalopathy (SIE) patients. In this prospective, single-center randomized controlled study, 112 patients with SIE were randomly assigned. Mean arterial pressure (MAP) and norepinephrine (NE) titration were guided via the TCD pulsatility index to achieve a pulsatility index 
ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-024-02814-0