The Flavoproteome of the Model Plant Arabidopsis thaliana

Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential cofactors for enzymes, which catalyze a broad spectrum of vital reactions. This paper intends to compile all potential FAD/FMN-binding proteins encoded by the genome of Several computational approaches were applied to gr...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-07, Vol.21 (15), p.5371
Main Authors: Schall, Patrick, Marutschke, Lucas, Grimm, Bernhard
Format: Article
Language:English
Subjects:
Adenine
Arabidopsis - genetics
Arabidopsis - metabolism
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
Binding
Binding sites
Biosynthesis
Chemical reactions
Cofactors
Computer applications
Cytoplasm
Enzymes
FAD
Flavin mononucleotide
Flavin Mononucleotide - genetics
Flavin Mononucleotide - metabolism
Flavin-adenine dinucleotide
Flavin-Adenine Dinucleotide - genetics
Flavin-Adenine Dinucleotide - metabolism
flavoenzymes
Flavoproteins
Flavoproteins - genetics
Flavoproteins - metabolism
FMN
Gene expression
Gene families
Genomes
Homology
Kinases
Localization
Metabolism
Mitochondria
Plastids
Protein families
Proteins
Proteome - genetics
Proteome - metabolism
riboflavin
Signal transduction
Transcription
Vitamin B
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Summary:Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential cofactors for enzymes, which catalyze a broad spectrum of vital reactions. This paper intends to compile all potential FAD/FMN-binding proteins encoded by the genome of Several computational approaches were applied to group the entire flavoproteome according to (i) different catalytic reactions in enzyme classes, (ii) the localization in subcellular compartments, (iii) different protein families and subclasses, and (iv) their classification to structural properties. Subsequently, the physiological significance of several of the larger flavoprotein families was highlighted. It is conclusive that plants, such as , use many flavoenzymes for plant-specific and pivotal metabolic activities during development and for signal transduction pathways in response to biotic and abiotic stress. Thereby, often two up to several homologous genes are found encoding proteins with high protein similarity. It is proposed that these gene families for flavoproteins reflect presumably their need for differential transcriptional control or the expression of similar proteins with modified flavin-binding properties or catalytic activities.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21155371