Circulating plasma IL-13 and periostin are dysregulated type 2 inflammatory biomarkers in prurigo nodularis: A cluster analysis

Prurigo nodularis (PN) is a chronic heterogeneous inflammatory skin disease. To elucidate which components of type 2 inflammation are dysregulated systemically in PN. Whole blood was obtained from PN patients with uncontrolled disease and control patients without pruritus. Plasma was assayed for IL-...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in medicine 2022-12, Vol.9, p.1011142-1011142
Main Authors: Parthasarathy, Varsha, Cravero, Karen, Deng, Junwen, Sun, Zhe, Engle, Sarah M, Auxier, Autum N, Hahn, Nathan, Sims, Jonathan T, Okragly, Angela J, Alphonse, Martin P, Kwatra, Shawn G
Format: Article
Language:English
Subjects:
IL-13
inflammation
itch
Medicine
prurigo
pruritus
Th2 (type-2) immune responses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prurigo nodularis (PN) is a chronic heterogeneous inflammatory skin disease. To elucidate which components of type 2 inflammation are dysregulated systemically in PN. Whole blood was obtained from PN patients with uncontrolled disease and control patients without pruritus. Plasma was assayed for IL-4, IL-5, IL-13, IgE, and periostin. ANOVA was utilized to compare PN and control patients and multiple-hypothesis adjusted value was calculated with the significance threshold at 0.05. Clustering was performed using K-means clustering. PN patients ( = 29) and controls ( = 18) from Johns Hopkins Dermatology had similar age sex, and race distributions. Single-plex assays of the biomarkers demonstrated elevated circulating plasma IL-13 (0.13 vs. 0.006 pg/mL, = 0.0008) and periostin (80.3 vs. 60.2 ng/mL, = 0.012) in PN compared to controls. IL-4 (0.11 vs. 0.02 pg/mL, = 0.30) and IL-5 (0.75 vs. 0.40 pg/mL, = 0.10) were not significantly elevated, while IgE approached significance (1202.0 vs. 432.7 ng/mL, = 0.08). Clustering of PN and control patients together revealed two clusters. Cluster 1 ( = 36) consisted of 18 PN patients and 18 controls. Cluster 2 ( = 11) consisted entirely of PN patients ( < 0.01). Cluster 2 had higher levels of IL-13 (0.33 vs. 0.008 pg/mL, = 0.0001) and IL-5 (1.22 vs. 0.43 pg/mL, = 0.03) compared to cluster 1. This study demonstrates elevation of IL-13 and periostin in the blood of PN patients, with distinct clusters with varying degrees of type 2 inflammation. Given this heterogeneity, future precision medicine approaches should be explored in the management of PN.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2022.1011142