Correlation between the graft-host junction of penetrating keratoplasty by anterior segment-optical coherence tomography and the magnitude of postoperative astigmatism

• Published in: Indian journal of ophthalmology 2017-07, Vol.65 (7), p.574-578
• Main Authors: Nassar, Ghada Azab, Arfeen, Shaimaa Abd El Salam
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Anterior Eye Segment - diagnostic imaging; Anterior segment-optical coherence tomography; Apposition; Astigmatism; Astigmatism - diagnosis; Astigmatism - etiology; Astigmatism - physiopathology; Care and treatment; CAT scans; Cornea; Corneal diseases; Corneal Diseases - diagnosis; Corneal Diseases - surgery; Corneal Topography; Corneal transplantation; Eye diseases; Eye surgery; Female; Follow-Up Studies; graft–host junction; Humans; Keratoplasty, Penetrating - methods; Male; Medical imaging; Middle Aged; Ophthalmology; Original; penetrating keratoplasty; postoperative astigmatism; Postoperative Complications - diagnosis; Postoperative Complications - etiology; Postoperative Complications - physiopathology; Refraction, Ocular - physiology; Retrospective Studies; Tomography; Tomography, Optical Coherence - methods; Topography; Transplants & implants; Treatment Outcome; Visual Acuity; Wounds; Young Adult
• ISSN: 0301-4738; 1998-3689
• DOI: 10.4103/ijo.IJO_820_16

This study aimed to evaluate the alignment pattern of the graft-host junction after penetrating keratoplasty (PK) by anterior segment-optical coherence tomography (AS-OCT) and to correlate this pattern with the magnitude of postoperative astigmatism. This retrospective observational study was carried out on forty patients who underwent PK from February 2013 to August 2014. AS-OCT was performed, and the graft-host junctions were classified into well-apposed junction, malapposed junction, and equally apposed junction. Mal-apposition is subdivided into gap and protrusion. The correlations between clinical characteristics, wound profiles from the AS-OCT, and the magnitude of postoperative astigmatism by Sirius camera (Costruzione Strumenti Oftalmici [CSO], Florence, Italy (CSO, Sirius), were analyzed. Graft-host junctions from forty patients were analyzed; 18 eyes had well-apposed junctions, ten eyes had malapposed junctions, and 12 had equally apposed junctions. The mean cylinder was -9.44 ± -4.00D in well-apposed group, -13.40 ± -5.01D in malapposed group, and -4.67 ± -0.94D in equally apposed group. Alignment pattern of the graft-host junction correlated significantly with the magnitude of astigmatism (P = 0.034). Preoperative corneal diseases did not have an effect on the magnitude of astigmatism (P = 0.123). The alignment pattern of the graft-host junction by AS-OCT can explain the postoperative astigmatism after PK where it correlates significantly with the magnitude of astigmatism.